- Available Technology
Keywords: Medical Devices, Biotechnology
Early-stage intervention of IVD degeneration
The biomimetic hydrogel scaffolds were created by decellularizing the NP isolated from cow tail IVDs utilizing chemical and physical methods. Cow NPs were used due to their similar geometry, size, and biochemical components as compared to the human NP. The decellularized NP has no residual bovine DNA, yet retains a significant amount of natural NP ECM, including both collagen type II and aggrecan, comparable to human NP. Additionally, the biomaterial has similar static and dynamic compressive properties as compared to healthy human NP tissue. This biomaterial fills a significant market need for the development of a biologic-based NP replacement targeting the early-stage intervention of IDD.
• Utilizes biomaterial formed from decellularized cow NP tissue via the application of a tissue-specific decellularization solution and procedure, resulting in a hydrogel that maintains bulk biochemical and mechanical properties similar to human NP
• Supports human cell viability, mitigating or halting IDD progression
• Can be produced via simple, repeatable, low cost batch process
Preliminary Prototype / Animal Model Studies
Jeremy Mercuri, Christopher Fernandez
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