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Market Overview

This hydrogel scaffold can be used as an early-stage intervention for combatting intervertebral disc (IVD) degeneration (IDD). Lower back pain is a significant burden that affects nearly 85 percent of all people, 40 percent of which are attributed to IDD. IVDs reside between the bones of the spine and contain the nucleus pulposus (NP) which is a resilient hydrogel core that generates intradiscal pressure to support compressive loading. IDD has been shown to initiate in the NP and results in IVD tissue disorganization, loss of intradiscal pressure and IVD height. Current treatments only mitigate pain and currently available biomaterials do not contain, nor do they mimic native the NP extracellular matrix (ECM) biochemistry or mechanical properties. Patients with early-stage IDD have no choice but to wait for degeneration to progress before warranting IVD replacement or fusion. Clemson University researchers have developed a biomaterial that mimics the structure and function of human NP to mitigate or halt progression of IDD.

Applications:

Early-stage intervention of IVD degeneration

Technical Summary:

The biomimetic hydrogel scaffolds were created by decellularizing the NP isolated from cow tail IVDs utilizing chemical and physical methods. Cow NPs were used due to their similar geometry, size, and biochemical components as compared to the human NP. The decellularized NP has no residual bovine DNA, yet retains a significant amount of natural NP ECM, including both collagen type II and aggrecan, comparable to human NP. Additionally, the biomaterial has similar static and dynamic compressive properties as compared to healthy human NP tissue. This biomaterial fills a significant market need for the development of a biologic-based NP replacement targeting the early-stage intervention of IDD.

Advantages:

• Utilizes biomaterial formed from decellularized cow NP tissue via the application of a tissue-specific decellularization solution and procedure, resulting in a hydrogel that maintains bulk biochemical and mechanical properties similar to human NP

• Supports human cell viability, mitigating or halting IDD progression

• Can be produced via simple, repeatable, low cost batch process

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Technology Overview

State of Development

Preliminary Prototype / Animal Model Studies

Category

Biomedical

Serial Number

62/215,475

CURF Reference No.

2015-048

Inventors

Jeremy Mercuri, Christopher Fernandez


For More Info, Contact:

Chris Gesswein

Executive Director, Director of Licensing agesswe@clemson.edu

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