Biotechnology

Biotechnology

Plant-Derived Extracellular Vesicles (PDEVs) for Therapeutics’ Vectors

Advanced Materials, Biomedical, Biotechnology

This technology applies to the isolation, purification, and recovery of extracellular vesicles from plant materials, referred to as plant-derived extracellular vesicles.  The exosome population of the PDEVs are employed for use as vectors for the delivery of therapeutics. Exosome vectors are a promising means for the treatment of many diseases, many of which are currently in clinical trials. Roots Analysis…

Fusogenic Peptides for Delivery of RNAi Therapeutics to Ovarian Cancer

Biomedical

The novel fusogenic peptides improve the delivery of therapeutics for ovarian cancer through their ability to enhance endosomal escape and delivery of bioactive therapeutics. Epithelial ovarian cancer is the 5th leading cancer among women, with a 49% five-year survival rate. Current treatment strategies for ovarian cancer include surgical removal, chemotherapy, and radiation; however, these treatments often prove ineffective or toxic…

Machine Learning Algorithm to Guide Cardiac Resynchronization Therapy Personalization

Biotechnology, Manufacturing

­This patient risk-assessment machine learning algorithm predicts patient response to cardiac resynchronization therapy (CRT) intervention enabling more informed selection criteria and improved rates of therapy success. Approximately 90,000 patients receive cardiac resynchronization therapy per year, with only 50% of that population benefitting. This directly results from the uncertainties surrounding which patients will actually benefit from the procedure. Providing insights into…
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