- Available Technologies
Nanotechnology, Biotechnology; Genomic sequencing
This nanopore device provides a way to identify small molecules by utilizing changes in electrical double layer capacitance and ionic current as well as the mobility rate of the analyte passing through the nanopores. This is done by driving an electrolyte solution containing identifiable molecules through a nanopore. Then, an electrical potential associated with the constant electrical current is applied to the nanopore and the ionic current through the nanopore is measured. Transient changes to the electrical potential, ionic current, and signal rate as the molecules move through the nanopore are detected and measured relative to a determined baseline. The magnitude of the electrical potential signal is correlated to the charge and size of the molecular analytes, allowing classification of different analytes. This device is reusable for multiple samples and because of the stable and repeatable signal transduction, it offers better reliability than similar approaches.
• Has capability of molecular and sub-molecular resolution, reducing the amount of sample needed for analysis
• Is reusable for multiple samples without noticeable degradation in performance, providing a cost effective means of identifying molecules
• Enables stable and repeatable signal transduction, resulting in a device that offers better reliability than similar technologies
Samuel Bearden, Guigen Zhang
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