- Available Technologies
Real-time, live cell imaging
In this method of super-resolution microscopy, interleaved solid and doughnut-shaped laser pulses are used to excite the biological sample, and the signal generated from each pulse is recorded. The signals between neighboring pulses are subtracted to effectively yield a shrunken point spread function, providing improved spatial resolution. The improvement factor is over two without deconvolution. This method uses only one laser at a single wavelength, which removes the need for high powered lasers used by other super-resolution microscopy techniques. The reduced power allows for imaging of live samples without damaging them. Low power pulsed lasers on the market cover a wide range of wavelengths, spanning from UV to near infrared. This allows for an unlimited selection of dyes or chromophores to use during the imaging process
Proof of concept
Tong Ye, Yang Li
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