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Keywords: Drug Discovery, Disease Treatment
Drug discovery, Neglected Tropical Disease Treatments
These compounds are diazocyclobutenes, synthesized via a novel and simple method, and could potentially be active against many different diseases. The compounds are currently demonstrated to be efficacious against Trypanosoma brucei, and have a superior safety profile to some of the currently available drugs. They are active in the nano- to micro-molar range, which is crucial for the development of a pharmaceutical, and although the structure-function relationship is not well understood, they are non-toxic to mammalian cells, a drastic improvement over the arsenic-derived compounds currently used to treat the disease.
• Novel synthesis pathway is simple and high yielding, resulting in cheaper production costs and high volumes produced
• Novel compounds have never been used for treatment of any prior disease, reducing acquired pathogen resistance to practically zero
• Compounds are active against Trypanosoma brucei, but non toxic to mammalian cells, providing improved targeting and less patient toxicity than previously available treatments
Preliminary Data
Provisional
62/817,150
2019-019
Daniel Whitehead, Jim Morris
Chris Gesswein
Executive Director, Director of Licensing agesswe@clemson.edu
Contact
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