- Available Technology
Drug discovery, Neglected Tropical Disease Treatments
These compounds are diazocyclobutenes, synthesized via a novel and simple method, and could potentially be active against many different diseases. The compounds are currently demonstrated to be efficacious against Trypanosoma brucei, and have a superior safety profile to some of the currently available drugs. They are active in the nano- to micro-molar range, which is crucial for the development of a pharmaceutical, and although the structure-function relationship is not well understood, they are non-toxic to mammalian cells, a drastic improvement over the arsenic-derived compounds currently used to treat the disease.
• Novel synthesis pathway is simple and high yielding, resulting in cheaper production costs and high volumes produced
• Novel compounds have never been used for treatment of any prior disease, reducing acquired pathogen resistance to practically zero
• Compounds are active against Trypanosoma brucei, but non toxic to mammalian cells, providing improved targeting and less patient toxicity than previously available treatments
Daniel Whitehead, Jim Morris
Executive Director, Director of Licensing firstname.lastname@example.org
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