- Available Technology
Bioremediation; environmental contaminants
Overall, the results show that bisbenzimidazoles are excellent inhibitors of E. coli DNA topoisomerase I and also display good antibacterial activity. Additionally, and more importantly, the E. coli topoisomerase I inhibition is extremely selective as DNA gyrase and mammalian topoisomerases are not inhibited. Clemson University research findings suggest that the ternary complex formed by the bacterial topoisomerase I has distinct sites for small molecule recognition, as compared to those found in DNA gyrase and mammalian topoisomerases, and these differences could be further exploited for antibacterial drug development. Further studies to investigate the mechanism of antibacterial activity and enzyme inhibition are being investigated and will be reported in due course.
• Rendered animal co-products act as electron donors, stimulating microbial respiration of reducible environmental contaminants
• Animal co-products contain lipids plus protein, improving contaminant transformation rates
• Greatly reduces cost of bioremidiation technology, providing a cost-effective way to transform contaminants
• Rendered co-product electron donor cost can be 10-20% of conventional electron donors
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