- Available Technology
Keywords: Cardiovascular, Tissues
Medical, tissues engineering
This technology is an infarct model generated by oxygen deprivation of tissue microspheres. The 3D microtissues/organoids are grown in a controlled low oxygen environment, with non-viable levels of oxygen creating the region of damaged cells representing the "infarct" and creating a gradient of oxygen in the outer zones of the microsphere. This utilizes transport limitations of tissue engineering, as these spheres are not vascularized, and oxygen diffusion to
the center of the sphere is limited by its size. This serves to recreate the 3D structure of infarcted tissue, which damages the cells in a similar physiological manner to an actual infarct. This method can be used to model pathogenesis of infarction injury by tracking changes in microtissue genetics, structure, and function over time, screen patient-specific tissue-level response to infarction injury, such as Type I diabetes, drug screening for infarction injury response, as well as re-oxygenation/reperfusion injury.
In vitro data
Dr. Ying Mei
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