Protein Nano-Object Software for Biomolecular Modeling

This Protein Nano-Object Integrator (ProNOI) software allows for researchers to generate atomic-style geometrical objects in the desired shape and dimensions either from cry-electron photography or user-specified shape. Biomolecular modeling is important to address biological problems at the molecular level and to understand the interactions between molecules to predict behavior. This is especially useful for pharmaceutical development and within the general research community. Biological macromolecules must frequently be modeled in conjunction with nano-objects in order to understand their interactions. However, nano-objects are typically unavailable in commonly used modeling systems and the customization of these objects can be limited. Clemson University researchers have developed the versatile Protein Nano-Object Integrator (ProNOI) software which allows for modeling of nano-objects with biological macromolecules. An unlimited number of customizable objects can be created and combined with biological macromolecules. The objects can be tailored in regards to their position, size, shape, distributed charge, and surface or volumetric parameters depending on the user’s needs.