- Available Technology
Diagnostics; Targeted Drug Delivery
The use of polyethylene terephthalate (PET) capillary-channeled polymer (C-CP) fibers in a hydrophobic interaction chromatography (HIC) protocol has shown promise in efficiently and effectively isolating exosomes in laboratory settings, with scalable potential. The technology demonstrates the ability to collect nano-entities on a much faster time scale with comparable yields and size distributions compared to traditional methods of exosome isolation, including differential centrifugation and the ExoEasy Maxi kit (QIAGEN). The versatility of PET C-CP fibers allows surface modifications for exosome type-specific isolation, which would prove useful in medical diagnostics. The fibers provide opportunity for scalable separations, allowing for implementation in small, spin-down columns as well as on a preparative scale for bulk exosome isolation from bioreactors. Exosome isolation on such a large scale would enable their potential use as natural, biocompatible drug delivery vehicles.
Clinical proof of concept (cervical cancer)
Dr. R. Kenneth Marcus, Dr. Terri F. Bruce
Executive Director, Director of Licensing firstname.lastname@example.org
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