- Available Technology
Diagnostics; Targeted Drug Delivery
The use of polyethylene terephthalate (PET) capillary-channeled polymer (C-CP) fibers in a hydrophobic interaction chromatography (HIC) protocol has shown promise in efficiently and effectively isolating exosomes in laboratory settings, with scalable potential. The technology demonstrates the ability to collect nano-entities on a much faster time scale with comparable yields and size distributions compared to traditional methods of exosome isolation, including differential centrifugation and the ExoEasy Maxi kit (QIAGEN). The versatility of PET C-CP fibers allows surface modifications for exosome type-specific isolation, which would prove useful in medical diagnostics. The fibers provide opportunity for scalable separations, allowing for implementation in small, spin-down columns as well as on a preparative scale for bulk exosome isolation from bioreactors. Exosome isolation on such a large scale would enable their potential use as natural, biocompatible drug delivery vehicles.
Clinical proof of concept (cervical cancer)
Dr. R. Kenneth Marcus, Dr. Terri F. Bruce
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