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These polymer fibers, used as stationary phases in high-performance liquid chromatography (HPLC), enable a high level of selectivity and throughput, thus increasing efficiency. Chromatography is a method used by scientists to separate organic and inorganic compounds for further analysis. Currently, over 60% of chemical analysis worldwide is done in conjunction with some form of chromatography. The global market for chromatography media was valued at $372.3 million in 2018 and is expected to reach $528.1 million by 2023. Because of the rising role of biopharmaceuticals, there is increasing need in the market for specialized phases to isolate specific proteins. This technology has the potential to fill this need in the market.
Richard Kenneth Marcus
Kenneth Christensen
2012-094

Applications:

Selective bioassays for high performance liquid chromatography

Technical Summary:

This technology us used as the stationary phase in HPLC, featuring a novel polymeric fiber support that is modified with a series of bi-functional lipid molecules. The molecules are composed of anchoring “legs” which can be of varying hydrophobicity, from alkanes to polyethylene glycol chains. The functional head groups be customized to possess functional groups such as NH3, COOH, or biotin. The lipids can can be further modified with virtually an unlimited number of head groups, chosen such that the target species in the mobile phase can have varying degrees of affinity.

Advantages:

• Customizable lipid head groups allow for control of solute interacting in chromatography
• Micron-sized channels that span entire length of column allowing for faster flow rates and minimal backpressure
• High surface area on polymers, improving mass transfer

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Technology Overview

State of Development

Functional Prototype

Patent Type

Utility

Category

Biotechnology

Serial Number

14/333,561

CURF Reference No.

2012-094

Inventors

Richard Kenneth Marcus, Kenneth Christensen


For More Info, Contact:

Chris Gesswein

Executive Director, Director of Licensing agesswe@clemson.edu

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