- Available Technology
Antibacterial coatings; pharmaceuticals; antibiotics
Overall, the results show that bisbenzimidazoles are excellent inhibitors of E. coli DNA topoisomerase I and also display good antibacterial activity. Additionally, and more importantly, the E. coli topoisomerase I inhibition is extremely selective as DNA gyrase and mammalian topoisomerases are not inhibited. Clemson University research findings suggest that the ternary complex formed by the bacterial topoisomerase I has distinct sites for small molecule recognition, as compared to those found in DNA gyrase and mammalian topoisomerases, and these differences could be further exploited for antibacterial drug development. Further studies to investigate the mechanism of antibacterial activity and enzyme inhibition are being investigated and will be reported in due course.
• Utilizes new compounds that take longer to develop bacterial resistance, offering relevant clinical
• Meets market demand for new agents, improving patient care and accessibility to needed antibacterial drugs
Dev Arya, Nihar Ranjan, Fenfei Leng
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