Clemson University Research Foundation makes strategic shift

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Established in 1981, the Clemson University Research Foundation (CURF) is a 501(c)(3) organization exclusively founded for charitable, educational, and scientific purposes. Since its founding, CURF’s main objective has been to encourage, promote, and support research, development, and related activities of Clemson University.  During its 37 years of operation, CURF has supported diverse research initiatives and facilitated technology transfer at Clemson University. In assisting Clemson faculty with moving their technologies out of the laboratory and into the commercial markets, CURF has served as a key connection between University faculty and industry.

 

Recently, CURF was challenged with an opportunity to strengthen their support of the CU Research Enterprise through a broader service offering and to reshape their brand in a way that will maximize their ability to operate at the convergence of multiple disciplines.  To meet such a challenge, CURF has partnered with The Brand Leader, a full-service branding firm, to clarify the CURF mission, values, and services to their primary stakeholders, increase visibility of their expanded support role, and promote opportunities for future collaborative research engagements between CU faculty and industry.

 

The power of the CURF brand lies in CURF’s ability to initiate and build research partnerships between Clemson faculty inventors and industry by leveraging its established core competencies in technology transfer, Intellectual Property, and business development. The basis of CURF’s success is relational and not transactional. In the past, the CURF brand has been primarily focused in marketing the technologies produced and disclosed by faculty researchers at Clemson. As CURF takes the steps to realign their brand with the ClemsonForward 2020 plan, the main focus of their brand will be geared towards providing faculty with the resources they need to promote not only their disclosed technologies, but also their research expertise and interests to a broader audience with the intent of contributing to an overall increase in high-impact research activities throughout the entire Research Enterprise.

 

After being in business for nearly four decades, CURF recognizes that the needs and interests of their diverse internal and external customers has evolved. It is CURF’s goal  to keep pace with the evolution of their customer base and their needs. Revising the CURF brand voice and strategically positioning their message with the ClemsonForward 2020 plan, will allow CURF to promote and guide their stakeholders to successful outcomes, not only in technology transfer, but in sponsored research engagements throughout the Institute.

 

Proving their mettle: Clemson bioengineering students create titanium detector for breast cancer surgery

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The best ideas can come at the oddest of times.

Just ask oncology surgeon Nancy DeMore. While performing a lumpectomy, she asked herself why there wasn’t an easier way to do the procedure that wouldn’t involve two invasive procedures.

DeMore, who’s also a researcher at the Medical University of South Carolina (MUSC), says it really wasn’t even a conscious thought. She just heard the question come out of her mouth and thought, Why not find out? And she knew just where to find a possible solution. She had done a talk at the 2015 Women’s Innovation Symposium at MUSC and met another presenter, Delphine Dean.

She was impressed by Dean, who holds a degree from MIT in electrical engineering and computer science and directs the Multiscale Bioelectromechanics Labat Clemson University. Instead of just passing off her idea, she picked up the phone.

She described the problem to Dean. When a patient has an abnormal mammogram and the radiologist takes a biopsy for a suspected cancer, a titanium clip is inserted to mark the tumor’s location. If the patient needs a lumpectomy, the patient goes to radiology where a wire is inserted into the breast to find the titanium clip. She then goes to the operating room, where the surgeon removes the breast tissue around the wire. This two-step process is inefficient and inconvenient for patients, and sometimes it’s painful.

Titanium is used because it’s not magnetically strong, so patients can have MRIs in the future and they won’t set off metal detectors at airports.

DeMore’s question: Would it be possible to make a metal detector that could detect titanium? Her hunch was that if the surgeon could find the location of the titanium clip in the operating room with the metal detector, it would eliminate the need for the wire.

Dean rose to the challenge, pitching the idea to students in her bioinstrumentation class who were intrigued by the project. Ideas and plans flew back and forth between MUSC and Clemson, with a group of Clemson students taking on the task and spending long hours in the lab.

Over time, all the brainstorming and work paid off. In August 2016, a patent was filed on the resulting hand-held detector. The prototype is set to go through pre-clinical trials and potentially will be on the market for use in two years, DeMore said.

Meanwhile, the idea and resulting design is getting rave reviews and winning awards. DeMore presented the ideaat the Charleston Southeast Medical Device Association Pitch Rounds competition at MUSC’s Drug Discovery Center, an event sponsored by MUSC and the Foundation for Research and Development. She won and now will be going on to compete in Atlanta later this month.

DeMore said it was a tough competition. “There were some other outstanding technologies that were equally as worthy, so I was really surprised. I’m really impressed with the technologies that are being developed in this region.”

DeMore also recently presented at the Society of Surgical Oncology’s “Innovations in the Operating Room” and won that competition.

DeMore noted she isn’t the only surgeon frustrated by a process that’s inefficient and inconvenient for patients.

“Surgeons constantly have ideas how to improve techniques because we’re the ones who are doing this every day. Many times we may have the ideas, but we have no idea of how to implement, so we just go on to our next patient.”

In this case, DeMore is glad she didn’t. It’s important for surgeons to be interested in bringing innovations to their field, she said, and the innovation competitions help.

“I’m so pleased to see the Society of Surgical Oncology put together the first session on innovations in the operating room, really highlighting the importance of this in our field.”

Team Science

What also really helps, though, are collaborations, DeMore said, adding how impressed she was with Dean’s team.

Dean agrees. “Sure, Clemson and MUSC are four hours apart, but it doesn’t feel that far apart. The Clemson-MUSC collaboration works really well. We make a lot of effort in our state to bridge that gap in the biomedical space.”

She’s seen the payoff with her students when they have the opportunity to work on real-world projects. “When you learn in a classroom by looking at slides and listening to lectures, it is very different from talking to a clinician who uses these devices,” she said.

Dean says she knows patients who’ve had to undergo the two-step process for a lumpectomy and how scary it was for them. It is gratifying to work on a project that will improve that experience and lower costs and her students benefitted from the clinical knowledge they got from DeMore, who has been very responsive. How well the device is being received has surprised all of them. “It blew up, and there’s been a lot of interest from the outside. It was eye-opening for the students. The MUSC tech transfer office moved things forward quickly.”

The project challenged her students. It took a “lot of tuning” and customization for clinical purposes and computational modeling, but the team kept working.

Clemson University senior Scott Slaney said it’s the most rewarding thing he’s ever done during college.

“We do a lot of learning about basic science behind these concepts, but seeing how all these moving pieces fit together to make a single working device is really a cool experience. To actually take something that sounds like it only has a few engineering principles and make it work in a medical environment is its own kind of beast to tackle. I was happy to learn about the need for this procedure and what seems to be an underserved community of the population,” he said.

Dean said students often bring passion to their projects, as can be seen in the students who worked on the project, including Slaney and classmate Joey Wilson, Clemson’s senior class president. As bioengineering students, they want to find creative solutions to problems within medicine, Wilson said.

“This is our ‘why’. This drives us and reminds us that this project is much bigger than ourselves. It could make a significant impact on the clinical cycle of care for hospitals and breast cancer patients, saving time, money and operating room space while preventing unnecessary human suffering.”

He really enjoyed the challenge of the project and taking a problem that no one has tackled to date.

“It’s why the status quo has been maintained for so long. For us, the reasoning of ‘It’s the way it has been done for a long time,’ is not sufficient. At Clemson and MUSC, I truly have surmised that we are thinkers, we are innovators and we are believers.”

Wilson said the project, though challenging, brought amazing opportunities to the team. The collaboration with DeMore and their research mentor, Dean, was critical. The team also learned how broad the field of bioengineering is, he said, adding that what they had to learn about metal detectors went far beyond the basics of their bioinstrumentation class.

“We had to find creative ways to educate ourselves about metal detectors and all of the components that make them work. The idea behind them is relatively simple, but all of the ways that operational metal detectors are created are complex and were out of the scope of our curriculum,” Wilson said.

When it got tough, team members reminded each other why they were there, Wilson said.

“We’re inspired by the opportunity to improve patient outcomes and change lives for the better. In the uphill battle against cancer, we’re making a little progress, and hopefully scientists will one day find a cure.”

Dean said she expects to see more of these collaborations in the future, particularly given how well this one worked.

“There’s no better way to teach our students than the real-world environment. It’s a win-win.”

It’s a win for MUSC as well, said DeMore. “It can save the patient from having to have the pain and inconvenience of having an invasive procedure to localize the clip, and it can improve the efficiency of the whole procedure for the patient and the hospital.”

*This article was originally published on the Clemson Newsstand. Read the full article here.*

Clemson’s 15 patents in 2016 span bioengineering, advanced materials

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Rapid diagnostic tests for point-of-care diagnostics, diabetic-resistant coatings, HIV inhibitors and an impact-resistant, corrosion-prohibiting coating were among the 15 innovations for which Clemson University researchers received patents in 2016.

Tanju Karanfil, vice president for research at Clemson University, says the patent awards are one example of the impact Clemson makes on the region. Image Credit: Craig Mahaffey / Clemson University

The Clemson University Research Foundation (CURF) facilitates and manages technology transfer for Clemson faculty. Collaboration between researchers and CURF has produced more than 150 patents that are now available to the private sector for licensing.

The patent recipients received special recognition recently at an annual award event sponsored by the Clemson Inventors Club, a select group of faculty chosen for their high level of research activity, which often produces inventions.

“Invention and innovation in research are just a few ways Clemson impacts the world,” said Tanju Karanfil, vice president for research at Clemson. “Congratulations to all the inventors for their hard work and dedication to academic research.”

Bob Quinn, executive director of the South Carolina Research Authority(SCRA) outlined the new vision for the organization.

“The patent awards are a great representation of the innovation happening at Clemson,” Quinn said. “We were honored to be able to share how SCRA works with innovators to commercialize their technologies.”

“Our annual patent awards recognize the quality of the research being done at Clemson,” said Casey Porto, executive director of the foundation. “It’s a privilege to honor these researchers and celebrate their contributions to innovation that starts at Clemson and moves into the marketplace.”

For a complete list of 2016 Clemson patents and recipients, click here.

For a complete list of all patents awarded to Clemson faculty, click here.